旋毛虫病小鼠淋巴结细胞对绵羊红细胞的体内和体外反应

In vivo and in vitro responses to sheep erythrocytes by lymph node cells from mice with trichinellosis.

作者信息

Jones J F, Crandall C A, Crandall R B

出版信息

Clin Exp Immunol. 1984 Aug;57(2):301-6.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536115/

Abstract

Mice infected with Trichinella spiralis for 20 days have decreased numbers of plaque forming cells (PFC) in the draining lymph nodes following subcutaneous immunization with sheep erythrocytes. However, when immunized in vitro, lymph node cells from infected mice generate more PFC than normal controls. Splenectomy has no effect on suppression observed in vivo. There is a large increase in the proportion and numbers of B cells in the lymph nodes of infected mice, and these cells may account for the enhanced PFC responses in vitro.

摘要

感染旋毛虫20天的小鼠，在用绵羊红细胞进行皮下免疫后，引流淋巴结中的空斑形成细胞（PFC）数量减少。然而，在体外进行免疫时，感染小鼠的淋巴结细胞产生的PFC比正常对照更多。脾切除术对体内观察到的抑制作用没有影响。感染小鼠淋巴结中B细胞的比例和数量大幅增加，这些细胞可能是体外PFC反应增强的原因。

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本文引用的文献

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Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。

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Ascaris suum: immunoglobulin responses in mice.猪蛔虫：小鼠的免疫球蛋白反应

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The distribution of 51Cr-labeled lymphocytes into antigen-stimulated mice. Lymphocyte trapping.51铬标记淋巴细胞在抗原刺激小鼠体内的分布。淋巴细胞滞留。

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Endotoxin-stimulated spleen cells: mitogenesis, the occurrence of the C3 receptor, and the production of immunoglobulin.内毒素刺激的脾细胞：有丝分裂、C3受体的出现及免疫球蛋白的产生。

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Immune responses in vitro. I. Culture conditions for antibody synthesis.体外免疫反应。I. 抗体合成的培养条件。

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7

Immunosuppression and increased susceptibility to Japaneses B encephalitis virus in Trichinella spiralis-infected mice.旋毛虫感染小鼠的免疫抑制及对日本乙型脑炎病毒易感性增加

Proc Soc Exp Biol Med. 1973 Jun;143(2):469-73. doi: 10.3181/00379727-143-37345.

8

Antigenic competition between two sequentially acting antigens. Immunosuppressive effect of T cells in spleen and lymph nodes of mouse.两种相继作用的抗原之间的抗原竞争。小鼠脾脏和淋巴结中T细胞的免疫抑制作用。

J Immunol. 1975 Sep;115(3):644-7.

9

T-dependent suppression of the primary antibody response to sheep erythrocytes in mice infected with Trichinella spiralis.旋毛虫感染小鼠中对绵羊红细胞的初次抗体应答的T细胞依赖性抑制

Cell Immunol. 1976 Nov;27(1):102-10. doi: 10.1016/0008-8749(76)90158-1.

10

Trichinella spiralis: changes caused in the mouse's thymic, splenic, and lymph node cell populations.旋毛虫：对小鼠胸腺、脾脏和淋巴结细胞群造成的变化。

Exp Parasitol. 1978 Jun;45(1):116-27. doi: 10.1016/0014-4894(78)90051-6.

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