MacSween J M, Eastwood S L, Cohen A D, Rajaraman K, Fox R A
Clin Immunol Immunopathol. 1984 Sep;32(3):368-77. doi: 10.1016/0090-1229(84)90280-0.
Stimulation of human lymphocytes with concanavalin A (Con A) resulted in variable lymphokine responses as indicated by factors inhibiting macrophage migration (MIF) or stimulating macrophage migration (MStF), or resulted in negligible responses. These responses were consistent for a given individual when repeated after several months. MIF responses were observed more frequently than MStF responses in patients with renal failure who had demonstrable alloantibodies. MStF responses were statistically associated with the presence of HLA DR1 antigens in patients with renal failure and two separate groups of healthy individuals, while MIF responses were associated with DR7 in the three groups studied. There was no correlation between immunoglobulin allotypes and lymphokine responses. These results suggest that lymphokine responses to Con A are indicators of nonspecific immunological responsiveness and are influenced by genes associated with the major histocompatibility complex.
用刀豆球蛋白A（伴刀豆球蛋白A，Con A）刺激人淋巴细胞，会产生不同的淋巴因子反应，表现为抑制巨噬细胞游走的因子（MIF）或刺激巨噬细胞游走的因子（MStF），或者反应可忽略不计。当在几个月后重复检测时，这些反应对于给定个体是一致的。在有可证实的同种抗体的肾衰竭患者中，观察到MIF反应比MStF反应更频繁。在肾衰竭患者和两组不同的健康个体中，MStF反应与HLA DR1抗原的存在在统计学上相关，而在研究的三组中，MIF反应与DR7相关。免疫球蛋白同种异型与淋巴因子反应之间没有相关性。这些结果表明，对Con A的淋巴因子反应是非特异性免疫反应性的指标，并受与主要组织相容性复合体相关的基因影响。
