DR和非DR Ia同种异型与乳糜泻易感性相关。
DR and non-DR Ia allotypes are associated with susceptibility to coeliac disease.
作者信息
Corazza G R, Tabacchi P, Frisoni M, Prati C, Gasbarrini G
出版信息
Gut. 1985 Nov;26(11):1210-3. doi: 10.1136/gut.26.11.1210.
Abstract
We have studied the frequency of HLA-DR, -MT, and -MB antigens in adult patients with coeliac disease and in a group of healthy controls, evaluating the strength of the observed associations by measuring the aetiologic fractions. Among the antigens significantly associated with coeliac disease, MB2 (DQw2) showed an aetiologic fraction higher than those of DR3 and DR7. Our results suggest that MB2, as associated more frequently than other specificities with a hypothetical disease predisposing gene, may play a role in the pathogenesis of coeliac disease. The significant association of DR3 and DR7 with coeliac disease may be ascribed to linkage disequilibrium of these antigens with MB2.
摘要
我们研究了乳糜泻成年患者及一组健康对照中HLA - DR、- MT和 - MB抗原的频率，并通过测量病因分数评估所观察到的关联强度。在与乳糜泻显著相关的抗原中，MB2（DQw2）显示出比DR3和DR7更高的病因分数。我们的结果表明，MB2与一个假设的疾病易感基因的关联比其他特异性更为频繁，可能在乳糜泻的发病机制中起作用。DR3和DR7与乳糜泻的显著关联可能归因于这些抗原与MB2的连锁不平衡。
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