Svennevig J L, Bugge-Asperheim B, Vaage J, Geiran O, Birkeland S
Injury. 1984 Sep;16(2):80-4. doi: 10.1016/s0020-1383(84)80002-9.
In a prospective, controlled study, the effects of large doses of methylprednisolone sodium succinate (MP) were examined in patients subjected to severe blunt injury of the chest. Forty patients with multiple fractures of ribs were selected for the study. The majority of the patients had associated extrathoracic injuries. Chest X-ray films revealed changes characteristic of pulmonary contusion in all cases. Twenty patients were given MP 30 mg/kg body weight intravenously and were compared with 20 patients receiving no steroids, but who were otherwise treated identically. There were no differences between the two groups with respect to the A-VO2 difference and intrapulmonary shunting. However, the steroid treatment led to a significant reduction in pulmonary vascular resistance and to a reduction of the work of the right side of the heart. The number of complications and periods of artificial respiration were reduced in the steroid group. All patients survived.
在一项前瞻性对照研究中，对遭受严重胸部钝性损伤的患者进行了大剂量琥珀酸钠甲泼尼龙（MP）疗效的研究。选取40例肋骨多发骨折患者进行该研究。大多数患者伴有胸外损伤。所有病例的胸部X光片均显示有肺挫伤的特征性改变。20例患者静脉注射30mg/kg体重的MP，并与20例未接受类固醇治疗但其他治疗相同的患者进行比较。两组在动静脉氧分压差和肺内分流方面无差异。然而，类固醇治疗使肺血管阻力显著降低，右侧心脏的工作量减少。类固醇治疗组的并发症数量和人工呼吸时间减少。所有患者均存活。
