Svennevig J L, Bugge-Asperheim B, Bjørgo S, Kleppe H, Birkeland S
Scand J Thorac Cardiovasc Surg. 1980;14(3):301-5. doi: 10.3109/14017438009101016.
The effects of large doses of methylprednisolone (MP) (30 mg per kg. b.w.) in patients with lung contusion following blunt chest trauma were studied in 10 patients selected at random and compared with 10 chest trauma patients receiving no steroids, but otherwise treated in the same way. All patients survived. Serious post-traumatic complications were reduced in the steroid group. All patients were followed with haemodynamic and metabolic observations for 6 weeks using Swan-Ganz flow directed thermodilution catheters. The most pronounced effect of MP was a significant reduction of pulmonary vascular resistance which may prevent right heart failure. The study demonstrates that MP should be given in sufficient doses in patients with respiratory insufficiency following blunt chest trauma.
对10例随机选取的钝性胸部创伤后肺挫伤患者，研究了大剂量甲基泼尼松龙（MP）（30毫克/千克体重）的效果，并与10例未接受类固醇治疗但其他治疗方式相同的胸部创伤患者进行比较。所有患者均存活。类固醇组的严重创伤后并发症减少。使用Swan-Ganz血流导向热稀释导管，对所有患者进行了6周的血流动力学和代谢观察。MP最显著的作用是显著降低肺血管阻力，这可能预防右心衰竭。该研究表明，钝性胸部创伤后呼吸功能不全的患者应给予足够剂量的MP。
