Batzri S, Gardner J D
Biochim Biophys Acta. 1978 Apr 4;508(2):328-38. doi: 10.1016/0005-2736(78)90335-8.
Dispersed mucosal cells (approx. 70% parietal cells) prepared from guinea pig stomach maintained their cellular concentration of potassium (65--80 nmol potassium/10(6) cells) for at least 5 h in vitro. Uptake of 42K by dispersed gastric mucosal cells depended on temperature, H+ concentration and oxidative metabolism. Carbachol and, in some instances, gastrin caused a 40--50% increase in cellular uptake of 42K as a consequence of the ability of these agents to increase 42K influx. Ouabain reduced uptake of 42K by 70% but did not alter the effect of carbachol. Cellular uptake of 42K was not altered by histamine, prostaglandin, E1, glucagon, secretin, vasoactive intestinal peptide or C-terminal octapeptide of cholecystokinin. Uptake of 42K was also increased by dibutyryl cyclic AMP or dibutyryl cyclic GMP but not by cyclic AMP, cyclic GMP or their 8-bromo derivatives. Theophylline caused a small (10--15%) increase in 42K uptake and potentiated the increase caused by submaximal concentrations of carbachol. The increase in 42K uptake caused by either dibutyryl cyclic nucleotide and carbachol was additive.
从豚鼠胃制备的分散黏膜细胞（约70%为壁细胞）在体外至少5小时内保持其细胞内钾浓度（65 - 80 nmol钾/10⁶个细胞）。分散的胃黏膜细胞对⁴²K的摄取取决于温度、H⁺浓度和氧化代谢。卡巴胆碱以及在某些情况下胃泌素可使⁴²K的细胞摄取增加40 - 50%，这是由于这些药物能够增加⁴²K的内流。哇巴因可使⁴²K的摄取减少70%，但不改变卡巴胆碱的作用。组胺、前列腺素E₁、胰高血糖素、促胰液素、血管活性肠肽或胆囊收缩素C末端八肽对⁴²K的细胞摄取没有影响。二丁酰环磷腺苷或二丁酰环磷鸟苷也可增加⁴²K的摄取，但环磷腺苷、环磷鸟苷或其8 - 溴衍生物则无此作用。茶碱可使⁴²K摄取略有增加（10 - 15%），并增强次最大浓度卡巴胆碱所引起的摄取增加。二丁酰环核苷酸和卡巴胆碱所引起的⁴²K摄取增加具有相加作用。
