Janowsky D S, Byerley B
J Clin Psychiatry. 1984 Oct;45(10 Pt 2):3-9.
It is proposed that factors including a long "track record," perceived lack of anticholinergic effects, suggestions of earlier onset of action, and the concept of noradrenergic specificity have contributed to the widespread clinical use of desipramine. Recent studies bearing on these clinical beliefs are reviewed, with a focus on desipramine side effects, specificity, and speed of onset as compared to other tricyclics and to new generation antidepressants.
有人提出，包括悠久的“应用记录”、被认为缺乏抗胆碱能作用、起效较早的迹象以及去甲肾上腺素能特异性的概念等因素，促使地昔帕明在临床上得到广泛应用。本文回顾了有关这些临床观点的近期研究，重点在于地昔帕明与其他三环类药物及新一代抗抑郁药相比的副作用、特异性和起效速度。
