Hiroshige T
J Auton Nerv Syst. 1984 May-Jun;10(3-4):337-46. doi: 10.1016/0165-1838(84)90031-6.
In this review, attempts were made to clarify the role of feeding behavior in modifying the basal 24-h pattern of plasma corticosterone in freely moving rats. An ethosecretogram, consisting of locomotor activity and plasma corticosterone levels in conscious rats over a period of several hours, was constructed. By analyzing the ethosecretogram, it was found that the feeding effectively induced an elevation of plasma corticosterone. Conscious rats were then exposed to various kinds of feeding regimens, emphasis being laid on the effect of restricted daily feeding on the circadian skeleton of plasma hormone rhythm. We found that feeding has a bidirectional effect on hormone level along with an initiation of an interval timer mechanism which in turn uniquely modify the basal pattern of circadian hormone rhythm, especially when a pre-feeding hormone peak is formed under restricted daily feeding schedules. Furthermore, it was shown that the pre-feeding hormone peak persisted after the termination of restricted feeding and free-ran in parallel with the circadian hormone peak. It is concluded that the pre-feeding hormone peak is driven by a damped oscillator which is entrainable to restricted feeding. It is most likely that this damped oscillator is loosely driven by the circadian oscillator which is not entrainable to restricted feeding.
在本综述中，我们试图阐明进食行为在改变自由活动大鼠血浆皮质酮的基础24小时模式中的作用。构建了一个行为分泌图，它由清醒大鼠数小时内的运动活动和血浆皮质酮水平组成。通过分析行为分泌图，发现进食能有效诱导血浆皮质酮升高。然后让清醒大鼠接受各种进食方案，重点关注每日限时进食对血浆激素节律昼夜框架的影响。我们发现，进食对激素水平有双向作用，同时启动了一个间隔定时器机制，该机制反过来又独特地改变了昼夜激素节律的基础模式，特别是在每日限时进食方案下形成进食前激素峰值时。此外，研究表明，进食前激素峰值在限时进食结束后持续存在，并与昼夜激素峰值并行自由运转。得出的结论是，进食前激素峰值由一个可被限时进食 entrain 的阻尼振荡器驱动。很可能这个阻尼振荡器由一个不可被限时进食 entrain 的昼夜振荡器松散驱动。
