Fiddian-Green R G, Bank S, Marks I N, Louw J H
Lancet. 1976 Dec 25;2(8000):1370-3. doi: 10.1016/s0140-6736(76)91916-4.
In a retrospective analysis of 2218 tests of gastric secretion 27% of patients with duodenal ulcers had an abnormal capacity to secrete acid. The abnormality was evident only in patients who had had symptoms for longer than three years, and was greatest in patients who had had symptoms for six to nine years. There was no significant difference between the capacity to secretic acid in patients who had symptoms of duodenal ulcer for less than three years and the capacity to secretic acid in normal controls. The tendency for the capacity to secrete acid to increase with duration of symptoms was also evident in patients with gastric ulcers. The positions in which ulcers were found were closely related to the maximum acid output (M.A.O.), and to the age of patients. The site of recurrent ulcers, after vagotomy and drainage, was also related to the M.A.O. after vagotomy. These influences of ageing and vagotomy on the site of ulcers can be attributed to their antecedent effect on the M.A.O. It is suggested that the capacity to secret acid alone is not responsible for the genesis of peptic ulcers but that it influences the position in which an ulcer may develop under the influence of an unknown ulcerogenic factor.
在一项对2218例胃液分泌检测的回顾性分析中，27%的十二指肠溃疡患者胃酸分泌能力异常。这种异常仅在有症状超过三年的患者中明显，在有症状六至九年的患者中最为显著。十二指肠溃疡症状持续时间少于三年的患者胃酸分泌能力与正常对照组的胃酸分泌能力之间无显著差异。胃溃疡患者中，胃酸分泌能力随症状持续时间增加的趋势也很明显。溃疡的发现部位与最大酸排量（M.A.O.）以及患者年龄密切相关。迷走神经切断术和引流术后复发性溃疡的部位也与迷走神经切断术后的M.A.O.有关。衰老和迷走神经切断术对溃疡部位的这些影响可归因于它们对M.A.O.的先前作用。有人提出，仅胃酸分泌能力并非消化性溃疡发生的原因，但它会影响在未知致溃疡因素影响下溃疡可能发展的位置。
