Naruse M, Naruse K, Shizume K, Inagami T
Proc Soc Exp Biol Med. 1984 Nov;177(2):337-42. doi: 10.3181/00379727-177-41953.
Using specific anti-rat renal renin antibody, the presence of renin in the rat testis was demonstrated by biochemical determination of renin activity. There was no correlation between testicular and plasma renin activity, indicating independent control of testicular and plasma renin levels. Since specific immunohistochemical staining for renin had been observed exclusively in Leydig cells, the effects of hypophysectomy and gonadotropin treatment on the testicular renin were investigated. After hypophysectomy, renin level in the testis decreased significantly, whereas plasma renin was slightly increased. In contrast, testicular renin had remarkably increased through gonadotropin treatment. The results indicate the presence of gonadotropin-dependent renin in the Leydig cells, and suggest a role for it in regulating testicular functions.
使用特异性抗大鼠肾素抗体，通过肾素活性的生化测定证实了大鼠睾丸中存在肾素。睾丸和血浆肾素活性之间没有相关性，这表明睾丸和血浆肾素水平是独立控制的。由于仅在睾丸间质细胞中观察到肾素的特异性免疫组化染色，因此研究了垂体切除和促性腺激素治疗对睾丸肾素的影响。垂体切除后，睾丸中的肾素水平显著降低，而血浆肾素略有升高。相反，促性腺激素治疗后睾丸肾素显著增加。结果表明睾丸间质细胞中存在促性腺激素依赖性肾素，并提示其在调节睾丸功能中起作用。
