Benacerraf B R, Frigoletto F D, Bieber F R
Radiology. 1984 Nov;153(2):495-7. doi: 10.1148/radiology.153.2.6385109.
Abnormalities of the fetal face were identified by ultrasound in five cases. Abnormalities such as cleft lip and palate, cyclopia, and forms of holoprosencephaly were diagnosed prenatally. Two of the fetuses had trisomy 13. When facial abnormalities are identified a careful search of the fetus for associated anomalies is indicated; amniocentesis for genetic study may be desirable. In addition, evaluation of the fetal face may be useful when other fetal abnormalities are present.
超声检查发现5例胎儿面部异常。产前诊断出唇腭裂、独眼畸形和全前脑畸形等异常情况。其中2例胎儿患有13三体综合征。当发现面部异常时，需要仔细检查胎儿是否存在相关畸形；可能需要进行羊膜穿刺术进行遗传学研究。此外，当存在其他胎儿异常时，评估胎儿面部情况可能会有帮助。
