Saltzman D H, Benacerraf B R, Frigoletto F D
Am J Obstet Gynecol. 1986 Aug;155(2):377-9. doi: 10.1016/0002-9378(86)90833-1.
Fetal facial clefts were identified sonographically in 12 cases, 10 (83%) of which had other structural anomalies. When a facial cleft is diagnosed prenatally a careful search of the fetus for associated anomalies is indicated. With the finding of an autosomal trisomy in four of the 10 cases (40%) with associated anomalies, cytogenetic amniocentesis is desirable to aid in diagnosis and subsequent obstetric management of these patients.
