Egsmose C, Lund B, Bach Andersen R
Scand J Rheumatol. 1984;13(3):238-42. doi: 10.3109/03009748409100392.
In a triple-blind controlled study, significant pain alleviation (p less than 0.01) was registered in patients with osteoarthrosis (OA) of the hip in the first 24 h after hip joint distension. There was no significant difference between treatment with indoprofen (a new non-steroidal anti-inflammatory drug for intra-articular use) and placebo. Pain relief lasted for at least 12 weeks in approximately half of the patients, in whom a significant increase in joint mobility was registered. Intra-articular indoprofen was not superior to placebo as regards pain relief or increased joint mobility. These findings indicate that the effect of a single hip joint distension in OA is due to a mechanical distension of the joint capsule, perhaps involving disruption of local agglutinations, and not due to suppression of inflammation.
在一项三盲对照研究中，髋关节扩张后24小时内，髋关节骨关节炎（OA）患者的疼痛得到显著缓解（p小于0.01）。吲哚美辛（一种新的关节内使用的非甾体抗炎药）治疗与安慰剂治疗之间无显著差异。大约一半的患者疼痛缓解持续至少12周，这些患者的关节活动度显著增加。在缓解疼痛或增加关节活动度方面，关节内注射吲哚美辛并不优于安慰剂。这些发现表明，OA患者单次髋关节扩张的效果是由于关节囊的机械扩张，可能涉及局部粘连的破坏，而不是由于炎症的抑制。
