Schlein Y, Warburg A, Schnur L F, Le Blancq S M, Gunders A E
Trans R Soc Trop Med Hyg. 1984;78(4):480-4. doi: 10.1016/0035-9203(84)90067-1.
The reservoir animals, sandfly vectors and strains of Leishmania from foci in the southern region of Israel were studied. The rodent host species are: Psammomys obesus, Meriones crassus and probably Nesokia indica. The vector species are Phlebotomus papatasi, which were caught at all collecting sites and Ph. sergenti, which were collected in the area of the Dead Sea and in the Central Arava. Strains of Leishmania major isolated from rodents, vectors and man were serologically and enzymologically identical with regard to their excreted factor (EF) serotypes, their malate dehydrogenase (MDH), glucose-phosphate isomerase (GPI) and glucose-6-phosphate dehydrogenase (G6PDH) enzyme variant types, but exhibited three variant subtypes of 6-phosphogluconate dehydrogenase (6PGDH). The distribution of the 6PGDH subtypes correlates with three different geographical locations. Scarcity of water is the main factor limiting the biotopes of the sandflies and the spread of leishmaniasis. The subjects discussed are the dependence of sandfly distribution on rodent-burrow depth in arid areas and the inter-relationship between the leishmanial subtypes, vectors and hosts.
对以色列南部地区疫源地的保虫宿主、白蛉传播媒介及利什曼原虫菌株进行了研究。啮齿动物宿主种类有：肥尾沙鼠、粗尾沙鼠，可能还有印度地鼠。传播媒介种类为巴氏白蛉，在所有采集地点均有捕获，以及赛氏白蛉，在死海地区和中央阿拉瓦采集到。从啮齿动物、传播媒介和人类中分离出的硕大利什曼原虫菌株，就其排泄因子（EF）血清型、苹果酸脱氢酶（MDH）、葡萄糖磷酸异构酶（GPI）和葡萄糖-6-磷酸脱氢酶（G6PDH）酶变异类型而言，在血清学和酶学上是相同的，但表现出6-磷酸葡萄糖酸脱氢酶（6PGDH）的三种变异亚型。6PGDH亚型的分布与三个不同的地理位置相关。缺水是限制白蛉生物群落和利什曼病传播的主要因素。讨论的主题包括干旱地区白蛉分布对啮齿动物洞穴深度的依赖性以及利什曼原虫亚型、传播媒介和宿主之间的相互关系。
