Blazar B R, Hurd D D, Snover D C, Alexander J W, McGlave P B
Am J Med. 1984 Oct;77(4):645-51. doi: 10.1016/0002-9343(84)90355-3.
From November 1982 to September 1983, three cases of invasive infection due to Fusarium species were documented in bone marrow transplant recipients. Fusarium was cultured from discrete skin nodules (one patient), maxillary sinus (one patient), or from the blood and surgically excised nasal septum (one patient). All three isolates were resistant to 5-fluorocytosine, whereas only one isolate was resistant to amphotericin B. Although all three patients died, two of the patients had clearing of their Fusarium infection. From this experience and from a review of the literature, it is concluded that despite the dismal prognosis for immunocompromised patients with Fusarium, beneficial therapies would include systemic amphotericin B, local surgical resection, and possibly leukocyte transfusions.
1982年11月至1983年9月期间，有3例骨髓移植受者发生了镰刀菌属引起的侵袭性感染。在散在的皮肤结节（1例患者）、上颌窦（1例患者）或血液及手术切除的鼻中隔（1例患者）中培养出了镰刀菌。所有3株分离菌对5-氟胞嘧啶耐药，而仅1株分离菌对两性霉素B耐药。尽管所有3例患者均死亡，但其中2例患者的镰刀菌感染得到了清除。根据这一经验以及文献回顾得出结论，尽管免疫功能低下的镰刀菌感染患者预后不佳，但有益的治疗方法包括全身应用两性霉素B、局部手术切除以及可能的白细胞输注。
