Melcher G P, McGough D A, Fothergill A W, Norris C, Rinaldi M G
Department of Infectious Diseases, Wilford Hall U.S. Air Force Medical Center, Lackland AFB, Texas 78236-5300.
J Clin Microbiol. 1993 Jun;31(6):1461-7. doi: 10.1128/jcm.31.6.1461-1467.1993.
Fusarium species are saprophytic molds and important plant pathogens, although they are increasingly recognized as agents of human mycosis. Frequently, the infection is superficial. Deep tissue infection may occur as an opportunistic hyalohyphomycosis, and wide dissemination is common in immunocompromised hosts. We describe a novel case of disseminated hyalohyphomycosis caused by F. napiforme in a patient with acute myelogenous leukemia. The clinical manifestations of this infection were similar to those attributed to infection with other species. In vitro susceptibility testing demonstrated resistance to amphotericin B and flucytosine, and progressive infection was documented until recovery of granulocyte function. The distinguishing clinical mycologic characteristics of this opportunistic mold are the unique turnip- or lemon-shaped microconidia. F. napiforme is a new agent of hyalohyphomycosis, further emphasizing the importance of Fusarium species as opportunistic molds.
镰刀菌属是腐生霉菌和重要的植物病原体，尽管它们越来越被认为是人类真菌病的病原体。通常，感染为浅表性。深部组织感染可能作为机会性透明丝孢霉病发生，在免疫功能低下的宿主中广泛播散很常见。我们描述了1例由芜菁状镰刀菌引起的播散性透明丝孢霉病的新病例，该患者患有急性髓性白血病。这种感染的临床表现与其他菌种感染所致的表现相似。体外药敏试验显示对两性霉素B和氟胞嘧啶耐药，并且在粒细胞功能恢复之前记录到了进行性感染。这种机会性霉菌独特的临床真菌学特征是具有独特的芜菁形或柠檬形小分生孢子。芜菁状镰刀菌是透明丝孢霉病的一种新病原体，进一步强调了镰刀菌属作为机会性霉菌的重要性。
