Privitera G, Bonino S, Del Mastro S
Int J Clin Pharmacol Res. 1984;4(3):201-7.
Josamycin propionate, a tasteless josamycin derivative suitable for the preparation of paediatric oral suspension, was employed in a large, multicentre clinical study aimed at evaluating the effectiveness and safety of the drug. Two hundred paediatric practitioners participated in the study, and 1908 children (mean age 5.27 years) were treated. Respiratory and pararespiratory infections were the most common diagnosis. The mean daily dose of josamycin was 53.5 mg/kg and the drug was administered for an average of 7.31 days. Josamycin proved to be a highly effective antimicrobial agent for the treatment of infections occurring in paediatric practice, with a success rate of 97.1%. The drug also showed a high degree of acceptance by the young patients and was very well tolerated: only 98 children (5.14%) developed side-effects during the treatment. However, the side-effects observed were reliably attributable to josamycin in only 10 out of 300 subjects who were not receiving other drugs; among these the frequency rate was 3.33%.
丙酸交沙霉素是一种无味的交沙霉素衍生物，适用于制备儿科口服混悬液，它被用于一项大型多中心临床研究，旨在评估该药物的有效性和安全性。两百名儿科医生参与了这项研究，共治疗了1908名儿童（平均年龄5.27岁）。呼吸道及呼吸道相关感染是最常见的诊断结果。交沙霉素的平均日剂量为53.5毫克/千克，给药平均时长为7.31天。交沙霉素被证明是治疗儿科临床感染的高效抗菌药物，成功率达97.1%。该药物在年轻患者中也获得了高度认可，耐受性良好：治疗期间只有98名儿童（5.14%）出现了副作用。然而，在未服用其他药物的300名受试者中，只有10人出现的副作用可确切归因于交沙霉素；其中发生率为3.33%。
