Flanders W D
Prostate. 1984;5(6):621-9. doi: 10.1002/pros.2990050608.
Prostate cancer is common among men in the United States. Factors of possible importance in the etiology of prostate cancer include diet, primarily implicated by ecologic studies of national, regional, and ethnic variation in rates; endocrine function, implicated by the importance of endocrine function in normal prostatic growth and in the treatment of prostate cancer; genetic susceptibility, supported by familial aggregation; some aspect of sexual behavior, suggested by case-control differences in sexual behavior; and occupational exposure, particularly cadmium exposure. Despite the public health importance of prostate cancer, it has received only moderate epidemiologic study; thus the etiologic importance of these and other possible determinants of prostate cancer risk is uncertain [55].
前列腺癌在美国男性中很常见。前列腺癌病因中可能具有重要意义的因素包括饮食，这主要是通过对国家、地区和种族发病率差异的生态学研究得出的；内分泌功能，鉴于内分泌功能在前列腺正常生长和前列腺癌治疗中的重要性；遗传易感性，有家族聚集现象作为支撑；性行为的某些方面，由病例对照研究中性行为的差异所提示；以及职业暴露，尤其是镉暴露。尽管前列腺癌具有公共卫生重要性，但它仅得到了适度的流行病学研究；因此，这些以及其他可能的前列腺癌风险决定因素在病因学上的重要性尚不确定[55]。
