Deniau J M, Lackner D, Feger J
Brain Res. 1978 Apr 21;145(1):27-35. doi: 10.1016/0006-8993(78)90793-x.
The effects of substantia nigra (SN) stimulation on the activity of the nucleus ventralis lateralis of the thalamus (VL) have been studied. The VL cells were identified as relay or non-relay cells among the cerebellothalamocortical pathway on the basis of orthodromical activation from the cerebellum and antidromical activation from the cortex. Certain experiments were performed after wide pericruciate decortication in order to eliminate the response due to unavoidable activation of corticofugal fibers. These results show that nigrothalamic neurons exert an inhibitory effect on VL cells. This inhibition was observed on the relay as well as on non-relay cells and was strong enought to suppress the cerebellar monosynaptic excitatory input. Thus the SN can modulate the information running along the cerebellothalamocortical pathway. The topographic localization of inhibited cells suggests that the SN controls the activity of the thalamic neurons which interfere with axial and proximal musculature.
已经研究了黑质（SN）刺激对丘脑腹外侧核（VL）活动的影响。根据来自小脑的顺行激活和来自皮质的逆行激活，在小脑-丘脑-皮质通路中，VL细胞被识别为中继细胞或非中继细胞。为了消除由于皮质离心纤维不可避免的激活而产生的反应，在广泛的十字交叉周围去皮质术后进行了某些实验。这些结果表明，黑质-丘脑神经元对VL细胞发挥抑制作用。在中继细胞和非中继细胞上均观察到这种抑制作用，并且这种抑制作用足够强以抑制小脑单突触兴奋性输入。因此，SN可以调节沿小脑-丘脑-皮质通路传递的信息。受抑制细胞的地形定位表明，SN控制着干扰轴向和近端肌肉组织的丘脑神经元的活动。
