通过对致死性照射大鼠红细胞中钠离子内流的研究来评估辐射防护剂。
Evaluation of radioprotectors by the Na+ influx study in RBC of lethally irradiated rats.
作者信息
Srinivasan M N, Basu S K, Ghose A
出版信息
Strahlentherapie. 1984 Sep;160(9):565-6.
PMID:6388052
Abstract
Sodium homeostasis in adult male albino Sprague Dawley rats has been examined 24 hours after exposure to 11 Gy whole-body gamma irradiation. Rate of influx of 22Na in red blood corpuscles (in vitro) of irradiated rats significantly increased and was modified by the administration of some radioprotective drugs prior to irradiation. Solcoseryl and AET (200 mg/kg) gave excellent protection and the combinations of 5-HTP with AET or MPG rendered better protection than when used alone.
摘要
在成年雄性白化斯普拉格-道利大鼠暴露于11戈瑞全身γ射线照射24小时后，对其钠稳态进行了检测。照射大鼠红细胞（体外）中22Na的流入速率显著增加，并且在照射前给予一些辐射防护药物可对其进行调节。索高捷疗和AET（200毫克/千克）提供了极佳的保护作用，5-羟色氨酸与AET或MPG联合使用时提供的保护作用比单独使用时更好。
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