Abraham A K, Neutze J M, MacCulloch D, Cornere B
Aust N Z J Med. 1984 Jun;14(3):223-6. doi: 10.1111/j.1445-5994.1984.tb03754.x.
Twenty cases of culture negative infective endocarditis admitted to the Cardiology Department of Green Lane Hospital from 1959 to 1980 out of a total of 265 cases (7.5%), were analysed retrospectively. Cases were included only when adequate proof of endocarditis was available at surgery or postmortem. Indiscriminate use of antibiotics before taking blood cultures was the most common association with failure to obtain positive cultures, seen in 16 of the 20 patients described. Failure to obtain positive cultures in four cases was attributed to inadequate bacteriologic techniques before 1967. Where no antibiotics were given prior to collecting blood cultures and bacteriologic techniques were adequate, proven culture negative endocarditis was virtually unknown. When antibiotics have been given, repeated blood cultures are recommended following withdrawal of antibiotic for at least four days.
1959年至1980年间，格林巷医院心内科共收治265例感染性心内膜炎患者，其中20例血培养阴性（占7.5%），对其进行回顾性分析。仅将手术或尸检时有充分心内膜炎证据的病例纳入研究。在采集血培养前滥用抗生素是血培养未能获得阳性结果的最常见原因，在所描述的20例患者中有16例出现这种情况。4例血培养未获阳性结果归因于1967年前细菌学技术不足。在采集血培养前未使用抗生素且细菌学技术充分的情况下，几乎不存在经证实的血培养阴性感染性心内膜炎。使用抗生素后，建议在停用抗生素至少4天后重复进行血培养。
