Etienne J, Fleurette J
Presse Med. 1985 Nov 23;14(40):2041-3.
We carried out 310 blood-cultures on samples from patients receiving antibiotics for either known or suspected infective endocarditis or suspected septicaemia. The culture bottles were inoculated either directly or after the antibiotics had been removed from the blood sample by the Antimicrobial Removal Device System. Out of 63 bacterial isolates from 21 patients (15 infective endocarditis and 6 septicaemias), 45 were made by both methods, 16 only after treatment with the Antimicrobial Removal Device System and two only after conventional culture. Of the 45 paired isolates, eight were cultured more rapidly after Antimicrobial Removal Device System treatment compared with none by conventional culture. The Antimicrobial Removal Device System thus significantly increased the number of positive cultures and the speed of their isolation. In practice, Antimicrobial Removal Device System treatment proved useful in five of the 21 cases, but delayed culture in one. Its greatest value was in showing persistent bacteraemia in patients being treated for prosthetic valve endocarditis.
我们对因已知或疑似感染性心内膜炎或疑似败血症而接受抗生素治疗的患者样本进行了310次血培养。培养瓶要么直接接种，要么在通过抗菌去除装置系统从血样中去除抗生素后接种。在从21名患者（15例感染性心内膜炎和6例败血症）中分离出的63株细菌中，45株是通过两种方法获得的，16株仅在使用抗菌去除装置系统处理后获得，2株仅通过传统培养获得。在45对配对分离株中，与传统培养无一例相比，8株在抗菌去除装置系统处理后培养速度更快。因此，抗菌去除装置系统显著增加了阳性培养物的数量及其分离速度。在实践中，抗菌去除装置系统治疗在21例中的5例中被证明是有用的，但有1例延迟了培养。其最大价值在于显示接受人工瓣膜心内膜炎治疗的患者存在持续性菌血症。
