Jayasundar S, Vohra M M
Can J Physiol Pharmacol. 1978 Apr;56(2):202-5. doi: 10.1139/y78-029.
The effect of uptake inhibitors on the spontaneous release of [3H]norepinephrine was studied using rat isolated vas deferens. Cocaine, desmethylimipramine, phenoxybenzamine, and guanethidine caused an increase in the spontaneous outflow of tritium, but did not alter the metabolic pattern of released [3H]norepinephrine. Bretylium caused an increase of both total tritium outflow and norepinephrine content. It is suggested that these drugs caused release of norepinephrine from storage sites and that norepinephrine was metabolized within the nerve terminals before reaching the biophase.
利用大鼠离体输精管研究了摄取抑制剂对[3H]去甲肾上腺素自发释放的影响。可卡因、去甲丙咪嗪、酚苄明和胍乙啶可导致氚的自发流出增加，但不改变释放的[3H]去甲肾上腺素的代谢模式。溴苄铵可导致总氚流出和去甲肾上腺素含量均增加。提示这些药物使去甲肾上腺素从储存部位释放，且去甲肾上腺素在到达生物相之前在神经末梢内被代谢。
