Young R J, Hannan W J, Frier B M, Steel J M, Duncan L J
Diabetes Care. 1984 Sep-Oct;7(5):479-80. doi: 10.2337/diacare.7.5.479.
The effect of lipohypertrophy at injection sites on insulin absorption has been studied in 12 insulin-dependent diabetic patients. The clearance of 125I-insulin from sites with lipohypertrophy was significantly slower than from complementary nonhypertrophied sites (% clearance in 3 h, 43.8 +/- 3.5 +/- SEM) control; 35.3 +/- 3.9 lipohypertrophy, P less than 0.05). The degree of the effect was variable but sufficient in several patients to be of clinical importance. Injection-site lipohypertrophy is another factor that modifies the absorption of subcutaneously injected insulin.
在12名胰岛素依赖型糖尿病患者中研究了注射部位脂肪增生对胰岛素吸收的影响。125I胰岛素从脂肪增生部位清除的速度明显慢于互补的非增生部位（3小时内清除率，对照组为43.8±3.5±标准误；脂肪增生部位为35.3±3.9，P<0.05）。这种影响的程度各不相同，但在几名患者中足以具有临床重要性。注射部位脂肪增生是另一个影响皮下注射胰岛素吸收的因素。
