McNally P G, Jowett N I, Kurinczuk J J, Peck R W, Hearnshaw J R
Leicester Royal Infirmary, UK.
Postgrad Med J. 1988 Nov;64(757):850-3. doi: 10.1136/pgmj.64.757.850.
Lipoatrophy and lipohypertrophy were the most frequently reported local complications of conventional insulin therapy. Early reports following the introduction of highly purified insulins suggested a reduction in the frequency of lipohypertrophy and lipoatrophy. Since highly purified insulins have been in common usage for 10 years, the present frequency of these complications was assessed in a study of 281 insulin treated diabetics. Lipohypertrophy was recorded in 76 (27.1%) patients including 3 with associated lipoatrophy. Lipoatrophy was found in 7 (2.5%) cases (3 porcine and 4 bovine insulin treated), 4 of which had only ever used highly purified insulins. Despite the introduction of highly purified insulins, lipohypertrophy and lipoatrophy remain prevalent in insulin treated patients. This common complication may be limited by routinely inspecting injection sites.
脂肪萎缩和脂肪肥大是传统胰岛素治疗中最常报告的局部并发症。高度纯化胰岛素引入后的早期报告表明，脂肪肥大和脂肪萎缩的发生率有所降低。由于高度纯化胰岛素已普遍使用了10年，因此在一项对281名接受胰岛素治疗的糖尿病患者的研究中评估了这些并发症目前的发生率。76名（27.1%）患者出现脂肪肥大，其中3例伴有脂肪萎缩。7例（2.5%）出现脂肪萎缩（3例使用猪胰岛素治疗，4例使用牛胰岛素治疗），其中4例仅使用过高度纯化胰岛素。尽管引入了高度纯化胰岛素，但脂肪肥大和脂肪萎缩在接受胰岛素治疗的患者中仍然很普遍。通过定期检查注射部位，这种常见并发症可能会得到控制。
