Danion J M, Brion S, Escande M, Ropert R, Sacquepee L, Singer L, Scotto J C
Encephale. 1984;10(3):135-8.
Anxiolytic effects and tolerance of a four weeks treatment with prazepam (single dose of 40 mg in the evening) and with lorazepam (3 daily doses of 1.25 mg) are compared in a double blind study. Patients were treated by psychiatrists and were suffering from neurotic anxiety. Evaluation for therapeutic efficacy used a clinical global improvement scale and the Hamilton Anxiety Scale. Evaluation for side effects used the side effects symptoms check list. Anxiolytic effects of prazepam and lorazepam are not significantly different. Tolerance of the two treatments is comparable. The side effects are essentially an undesirable sedative action.
在一项双盲研究中,比较了普拉西泮(每晚单剂量40毫克)和劳拉西泮(每日3次,每次1.25毫克)四周治疗的抗焦虑作用及耐受性。患者由精神科医生治疗,患有神经性焦虑症。治疗效果评估采用临床总体改善量表和汉密尔顿焦虑量表。副作用评估采用副作用症状检查表。普拉西泮和劳拉西泮的抗焦虑作用无显著差异。两种治疗的耐受性相当。副作用主要是不良的镇静作用。