Shimada K, Matsuda T, Inamatsu T, Urayama K
J Antimicrob Chemother. 1984 Sep;14 Suppl B:325-30. doi: 10.1093/jac/14.suppl_b.325.
Thirteen patients who were treated with cephem antibiotics developed blood coagulation disorders due to vitamin K deficiency. At the time of detection of prolongation of the prothrombin time, cefazolin was being administered in four cases, cefmetazole and latamoxef (moxalactam) in three cases each, and cefoperazone, cefpiramide and ceftazidime in one case each. Bleeding occurred in ten patients, but administration of vitamin K rapidly eliminated the prothrombin time prolongation and the haemorrhagic tendency. To date, we have not detected prothrombin time prolongation or a haemorrhagic tendency with cefotaxime, ceftizoxime, cefotiam, cefoxitin or cefsulodin. Thus, different cephem antibiotics show different effects on the prothrombin time.
13名接受头孢菌素类抗生素治疗的患者因维生素K缺乏而出现凝血功能障碍。在检测到凝血酶原时间延长时，4例患者正在使用头孢唑林，3例患者分别使用头孢美唑和拉氧头孢（羟羧氧酰胺菌素），1例患者分别使用头孢哌酮、头孢匹胺和头孢他啶。10例患者发生出血，但补充维生素K后凝血酶原时间延长和出血倾向迅速消除。迄今为止，我们尚未在使用头孢噻肟、头孢唑肟、头孢替安、头孢西丁或头孢磺啶的患者中检测到凝血酶原时间延长或出血倾向。因此，不同的头孢菌素类抗生素对凝血酶原时间有不同的影响。
