Sealey J E, Wilson M, Morganti A A, Zervoudakis I, Laragh J H
Clin Exp Hypertens A. 1982;4(11-12):2373-84. doi: 10.3109/10641968209062396.
Active and inactive renin were measured sequentially in 16 women throughout pregnancy and again post-partum. By 12 weeks, inactive renin was elevated 14-fold and fell slightly thereafter. By 12 weeks, active renin was 3.5-fold elevated. It continued to rise in 8 patients (Group A) until term, it remained stable in 6 (Group B) and in 2 it was quite variable. Between 12 and 32 weeks PRA and plasma aldosterone increased in Group A from 7.0 to 17.1 ng/ml/hr, and 20.0 to 95.7 ng/dl respectively and both were unchanged in Group B (6.5 to 8.1 ng/ml/hr and 26.5 to 24.6 ng/dl respectively). Inactive renin was higher in Group B than in Group A at 12 weeks (224 v 126 ng/ml/hr) but fell thereafter to the same stable but elevated level. Group A were younger (24 +/- 1.8 S.E. v. 30 +/- 2.2 years). These studies demonstrate that active and inactive renin increase early in pregnancy and remain elevated thereafter. In certain younger subjects, further increases in active renin and aldosterone sometimes occur and appear necessary for the maintenance of normal blood pressure.
在16名女性整个孕期及产后对活性肾素和非活性肾素进行了连续测量。到12周时，非活性肾素升高了14倍，此后略有下降。到12周时，活性肾素升高了3.5倍。8名患者（A组）的活性肾素持续上升直至足月，6名患者（B组）保持稳定，2名患者变化较大。在12至32周期间，A组的血浆肾素活性（PRA）和血浆醛固酮分别从7.0升至17.1 ng/ml/hr和从20.0升至95.7 ng/dl，而B组两者均无变化（分别为6.5至8.1 ng/ml/hr和26.5至24.6 ng/dl）。在12周时，B组的非活性肾素高于A组（224对126 ng/ml/hr），但此后降至相同的稳定但升高的水平。A组年龄更小（24±1.8标准误对30±2.2岁）。这些研究表明，活性肾素和非活性肾素在孕期早期升高，此后持续升高。在某些较年轻的受试者中，活性肾素和醛固酮有时会进一步升高，这似乎对维持正常血压是必要的。
