Houser M, Zimmerman B, Davidman M, Smith C, Sinaiko A, Fish A
Kidney Int. 1984 Aug;26(2):176-82. doi: 10.1038/ki.1984.152.
A patient with idiopathic hypercalciuria and some features suggestive of Bartter syndrome is reported. Excessive urinary prostaglandin E (PGE) excretion and renal calcium leak were documented in this child. Treatment with aspirin and indomethacin reduced urinary PGE excretion and was associated with a decrease in daily calcium excretion. At the lowest levels of urinary PGE, the renal calcium leak was no longer evident although mild hypercalciuria persisted. These results suggest that PGE may play a role in some cases of idiopathic hypercalciuria.
本文报告了一名患有特发性高钙尿症且具有一些提示巴特综合征特征的患者。该患儿存在尿前列腺素E（PGE）排泄过多和肾钙泄漏的情况。阿司匹林和吲哚美辛治疗可减少尿PGE排泄，并伴有每日钙排泄量的减少。在尿PGE处于最低水平时，尽管仍存在轻度高钙尿症，但肾钙泄漏不再明显。这些结果表明，PGE可能在某些特发性高钙尿症病例中起作用。
