Kohout I, Bachmann H
Abteilung für Nephrologie, Universitätsklinik für Kinderund, Jugendmedizin, Essen.
Monatsschr Kinderheilkd. 1987 Dec;135(12):847-50.
Out of five children with hypercalciuria, four had nephrocalcinosis and one recurrent bladder calculi. Two out of four patients with nephrocalcinosis (patients 1 and 2) had the "hyperprostaglandin E syndrome" and the other two (patients 3 and 4, siblings) had the Royer syndrome (osteopathy, dwarfism, secondary hyperparathyroidism). Treatment with hydrochlorothiazide is effective in patients without increased urinary excretion of prostaglandin, whereas patients with increased prostaglandin excretion respond better to indomethacin therapy.
