初始刺激因子在肿瘤坏死因子产生中的作用。
Role of first stimulating agents in the production of tumor necrosis factor.
作者信息
Haranaka K, Satomi N, Sakurai A, Haranaka R
出版信息
Cancer Immunol Immunother. 1984;18(2):87-90. doi: 10.1007/BF00205740.
The conditions and kinetics of tumor necrosis factor (TNF) production were examined. For TNF production, dual stimulation is necessary. Priming agents such as BCG, Corynebacterium parvum, and zymosan, which can stimulate the reticuloendothelial system (RES), are good substances for TNF production with the aid of lipopolysaccharide. Wide differences are observed in TNF producibility among different priming agents. The producibility of TNF depends on the degree of stimulation of the RES by the priming agents. Those priming agents, e.g., Propionibacterium acnes and Corynebacterium anaerobium, that are able to induce substantial RES hyperplasia are also able to induce high levels of TNF activity. Following administration of large doses of BCG or zymosan, mice were found to produce TNF activity. However, PPD, OK 432, PSK, and Choreito were unable to induce TNF activity.
对肿瘤坏死因子（TNF）产生的条件和动力学进行了研究。对于TNF的产生，双重刺激是必要的。能够刺激网状内皮系统（RES）的启动剂，如卡介苗、短小棒状杆菌和酵母聚糖，是借助脂多糖产生TNF的良好物质。不同启动剂之间的TNF产生能力存在很大差异。TNF的产生能力取决于启动剂对RES的刺激程度。那些能够诱导RES大量增生的启动剂，如痤疮丙酸杆菌和厌氧棒状杆菌，也能够诱导高水平的TNF活性。在给予大剂量卡介苗或酵母聚糖后，发现小鼠产生TNF活性。然而，结核菌素纯蛋白衍生物（PPD）、溶链菌制剂（OK 432）、云芝多糖（PSK）和草分枝杆菌制剂（Choreito）不能诱导TNF活性。
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