Salmon J H
Childs Brain. 1978;4(2):114-9. doi: 10.1159/000119767.
Very high intraventricular chloramphenicol levels can be obtained if the standard systemic dose is supplemented with a small intraventricular dose. Chloramphenicol sodium succinate can be hydrolyzed to the microbiologically active chloramphenicol in the ventricular fluid. Daily injections are ordinarily adequate to maintain a high concentration of antibiotic. Initial dosage should vary with ventricular volume. The brain does not tolerate repeated needle puncture and the use of a ventriculostomy reservoir is recommended.
如果在标准全身剂量基础上补充小剂量脑室内给药，可使脑室内氯霉素水平非常高。琥珀氯霉素钠可在脑室液中水解为具有微生物活性的氯霉素。通常每日注射足以维持高浓度抗生素。初始剂量应根据脑室容量而有所不同。大脑不耐受反复穿刺，建议使用脑室造瘘贮液器。
