利福霉素治疗新生儿黄杆菌脑膜炎。
Rifamycin in neonatal flavobacteria meningitis.
作者信息
Lee E L, Robinson M J, Thong M L, Puthucheary S D
出版信息
Arch Dis Child. 1976 Mar;51(3):209-13. doi: 10.1136/adc.51.3.209.
Abstract
Three newborn infants with meningitis due to Flavobacterium meningosepticum were treated with rifamycin administered parenterally and directly into the cerebral ventricles. Antibiotic concentrations of blood and cerebrospinal fluid (CSF) were monitored during treatment. There was rapid sterilization of the CSF after this antibiotic. Jaundice was the only toxicity noted. All 3 infants developed hydrocephalus and are shunt dependent. Two of them are otherwise free of neurological complications and are developing normally. Rifamycin is a safe and effective antibiotic in this form of neonatal meningitis.
摘要
三名患有脑膜炎败血金黄杆菌所致脑膜炎的新生儿接受了利福霉素治疗，给药途径为肠胃外注射并直接注入脑室。治疗期间监测了血液和脑脊液（CSF）中的抗生素浓度。使用这种抗生素后，脑脊液迅速实现无菌状态。观察到的唯一毒性反应是黄疸。所有3名婴儿均出现脑积水，依赖分流术。其中两名婴儿无其他神经并发症，发育正常。利福霉素对于这种类型的新生儿脑膜炎是一种安全有效的抗生素。
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