Chu A C
Dermatologica. 1984;169 Suppl 1:81-6. doi: 10.1159/000249644.
38 patients were entered into a controlled randomised trial, comparing two forms of topical treatment for pityriasis versicolor. Diagnosis was made on clinical criteria and confirmed by direct microscopic examination of Parker Quink/KOH preparations. 20 patients were treated with bifonazole solution daily for 2 weeks. 18 patients were treated with 2.5% selenium sulphide shampoo daily for one week and weekly for six weeks. Mycological examination showed that Malassezia furfur was present in all patients prior to treatment. At the end of the trial, 1 patient (5%) treated with bifonazole and 4 patients (22%) of those treated with selenium sulphide shampoo showed the presence of the fungus in the skin. This study demonstrates that bifonazole solution is an effective and well-tolerated form of treatment for pityriasis versicolor. A 2-week course of bifonazole solution was as effective as a 7-week course of selenium sulphide shampoo in eradicating the disease and had a lower relapse rate at 4 weeks.
38名患者进入一项对照随机试验，比较两种治疗花斑癣的局部治疗方法。根据临床标准进行诊断，并通过对派克墨水/氢氧化钾制剂的直接显微镜检查加以确认。20名患者每天使用联苯苄唑溶液治疗2周。18名患者每天使用2.5%硫化硒洗发水治疗1周，之后每周治疗1次，共治疗6周。真菌学检查显示，所有患者在治疗前均存在糠秕马拉色菌。试验结束时，接受联苯苄唑治疗的1名患者（5%）和接受硫化硒洗发水治疗的4名患者（22%）皮肤中仍存在真菌。本研究表明，联苯苄唑溶液是一种治疗花斑癣有效且耐受性良好的治疗方式。在根除疾病方面，2周疗程的联苯苄唑溶液与7周疗程的硫化硒洗发水效果相当，且在4周时复发率更低。
