5% 西伯蒿洗剂与 1% 克霉唑洗剂治疗花斑糠疹的随机对照临床试验
Randomized comparative clinical trial of Artemisia sieberi 5% lotion and clotrimazole 1% lotion for the treatment of pityriasis versicolor.
作者信息
Rad Farrokh, Aala Farzad, Reshadmanesh Naser, Yaghmaie Rokshana
机构信息
Besat Hospital, Sanandaj, Kurdistan, Iran.
出版信息
Indian J Dermatol. 2008;53(3):115-8. doi: 10.4103/0019-5154.43209.
AIMS
To compare the therapeutic effects of topical Artremisia sieberi 5% lotion with topical clotrimazole 1% lotion in the treatment of pityriasis versicolor.
MATERIALS AND METHODS
100 patients with pityriasis versicolor and microscopic identification of Malassezia furfur were randomly assigned to treatment with either topical Artemisia sieberi 5% lotion (group 1) or topical clotrimazole 1% lotion (group 2) for 2 weeks. Group 1 and group 2 consisted of 51 and 49 patients respectively. The patients were evaluated both clinically and mycologically at baseline and every 2 weeks for a period of 4 weeks.
RESULTS
At the end of the second week, clinical cure rates were 86.3% and 65.3% for group 1 and group 2 respectively (P<0.01), but at the same time mycological cure rate was 92.2% for group 1 and 73.5% for group 2 (P<0.05). At the end of the fourth week, clinical cure rates were 86.3% and 59.2% for group 1 and group 2 respectively (P<0.01), and at the same time mycologic cure rate was 96.1% for group 1 and 65.3% for group 2 (P<0.01).
CONCLUSIONS
The results of this study demonstrated that Artemisia sieberi 5% lotion was more effective than clotrimazole 1% lotion in the treatment of pityriasis versicolor.
目的
比较5% 茵陈蒿洗剂与1% 克霉唑洗剂局部治疗花斑糠疹的疗效。
材料与方法
100例经显微镜检查确诊为糠秕马拉色菌感染的花斑糠疹患者，随机分为两组，分别外用5% 茵陈蒿洗剂（第1组）和1% 克霉唑洗剂（第2组），疗程2周。第1组和第2组分别有51例和49例患者。在基线时以及之后的4周内，每2周对患者进行临床和真菌学评估。
结果
在第二周结束时，第1组和第2组的临床治愈率分别为86.3% 和65.3%（P<0.01），但与此同时，第1组的真菌学治愈率为92.2%，第2组为73.5%（P<0.05）。在第四周结束时，第1组和第2组的临床治愈率分别为86.3% 和59.2%（P<0.01），同时，第1组的真菌学治愈率为96.1%，第2组为65.3%（P<0.01）。
结论
本研究结果表明，5% 茵陈蒿洗剂治疗花斑糠疹的效果优于1% 克霉唑洗剂。
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