del Palacio Hernanz A, Delgado Vicente S, Menéndez Ramos F, Rodríguez-Noriega Belaustegui A
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S121-7. doi: 10.1093/clinids/9.supplement_1.s121.
Forty patients with pityriasis versicolor, fluorescence of involved areas under Wood's light, and positive microscopic identification of Malassezia furfur were randomly assigned to treatment with either oral itraconazole (200 mg once daily for five consecutive days) or 2.5% selenium sulfide shampoo (once daily application for seven days). Each treatment group consisted of 20 patients. On assessment three weeks after the end of treatment, all patients given itraconazole showed a response: 17 were healed, and three had mild residual lesions. Likewise, all patients in the selenium sulfide group responded to therapy: 16 were healed, and four had mild residual lesions. Tolerability, acceptability, and compliance were excellent with itraconazole. All 20 patients given the drug stated a preference for oral treatment. In the selenium sulfide group, five patients (25%) had adverse reactions attributable to the medication; one of these patients experienced an irritation severe enough to warrant the discontinuation of treatment on the third day. Ten patients in this group stated a preference for oral treatment.
40例患有花斑糠疹的患者，其受累部位在伍德灯下有荧光，且显微镜检查马拉色菌呈阳性，被随机分为两组，分别接受口服伊曲康唑（每日1次，每次200mg，连续服用5天）或2.5%硫化硒洗剂（每日使用1次，共7天）治疗。每个治疗组由20名患者组成。在治疗结束3周后的评估中，所有接受伊曲康唑治疗的患者均有反应：17例治愈，3例有轻度残留病变。同样，硫化硒组的所有患者对治疗均有反应：16例治愈，4例有轻度残留病变。伊曲康唑的耐受性、可接受性和依从性都很好。所有20例服用该药物的患者均表示倾向于口服治疗。在硫化硒组中，5例患者（25%）出现了与药物相关的不良反应；其中1例患者的刺激反应严重到足以使其在第三天停止治疗。该组中有10例患者表示倾向于口服治疗。
