Halliday W J, Maluish A E, Stephenson P M, Davis N C
Cancer Res. 1977 Jul;37(7 Pt 1):1962-71.
The leukocyte adherence inhibition technique was used to assess cell-mediated immunoreactivity and serum-blocking factors related to adenocarcinoma of the colon or rectum. In the group of 48 patients with confirmed tumors of this type, 36 of 38 had reactive leukocytes and 46 of 47 had serum-blocking factors. Patients whose tumors had been removed surgically, with no sign of recurrence, retained their leukocyte activity for up to 3.5 years in 6 of 6 cases, but only a small proportion (7 of 30) retained blocking factors. In 67 controls (who were patients with nonmalignant gastrointestinal disorders, patients with gastrointestinal tumors other than colorectal adenocarcinoma, patients with other cancers, or healthy volunteers), negative reactions were obtained, with diverticular disease the only prominent exception. The leukocyte adherence inhibition test appeared to be highly sensitive and specific. Application to the immunodiagnosis of colorectal cancer thus seems to be warranted.
采用白细胞黏附抑制技术评估与结肠或直肠癌相关的细胞介导免疫反应性和血清阻断因子。在48例确诊为此类肿瘤的患者组中，38例中有36例白细胞有反应，47例中有46例有血清阻断因子。肿瘤已通过手术切除且无复发迹象的患者，6例中有6例白细胞活性保持长达3.5年，但只有一小部分（30例中的7例）保留了阻断因子。在67名对照者（患有非恶性胃肠道疾病的患者、患有结直肠腺癌以外的胃肠道肿瘤的患者、患有其他癌症的患者或健康志愿者）中，除憩室病外均获得阴性反应，憩室病是唯一显著的例外。白细胞黏附抑制试验似乎具有高度敏感性和特异性。因此，将其应用于结直肠癌的免疫诊断似乎是合理的。
