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一种新型局部用抗真菌药物:噻康唑。

A new topical antifungal drug: tioconazole.

作者信息

Vander Ploeg D E, De Villez R L

出版信息

Int J Dermatol. 1984 Dec;23(10):681-3. doi: 10.1111/j.1365-4362.1984.tb01234.x.

DOI:10.1111/j.1365-4362.1984.tb01234.x
PMID:6396247
Abstract

Following 4 weeks of treatment, 32 of 35 tioconazole treated patients (91.4%) and 29 of 34 miconazole treated patients (85.3%) achieved clinical and mycologic cures. At follow-up four weeks after completion of treatment, 29 of 31 tioconazole treated patients (93.5%) and 25 of 28 miconazole treated patients (89.3%) remained cured. There was no significant difference between clinical, mycologic or clinical plus mycologic response to the two medications. The 96.2% positive culture correlation in this study is attributed to the selection of multiple culture sites.

摘要

治疗4周后,35例使用噻康唑治疗的患者中有32例(91.4%)以及34例使用咪康唑治疗的患者中有29例(85.3%)实现了临床和真菌学治愈。在治疗结束后4周的随访中,31例使用噻康唑治疗的患者中有29例(93.5%)以及28例使用咪康唑治疗的患者中有25例(89.3%)仍保持治愈状态。两种药物在临床、真菌学或临床加真菌学反应方面无显著差异。本研究中96.2%的阳性培养相关性归因于多个培养部位的选择。

相似文献

1
A new topical antifungal drug: tioconazole.一种新型局部用抗真菌药物:噻康唑。
Int J Dermatol. 1984 Dec;23(10):681-3. doi: 10.1111/j.1365-4362.1984.tb01234.x.
2
Treatment of dermatomycoses with topical tioconazole and miconazole.外用噻康唑和咪康唑治疗皮肤真菌病。
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[Double-blind comparative study of RO-13-8996 with miconazole in relation to its efficiency and local tolerance in patients with dermatomycosis].[RO-13-8996与咪康唑治疗皮肤真菌病的疗效及局部耐受性的双盲对照研究]
Med Cutan Ibero Lat Am. 1984;12(1):57-61.
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Mycoses. 1988 May;31(5):280-4.
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引用本文的文献

1
Topical antifungal treatments for tinea cruris and tinea corporis.股癣和体癣的外用抗真菌治疗。
Cochrane Database Syst Rev. 2014 Aug 4;2014(8):CD009992. doi: 10.1002/14651858.CD009992.pub2.
2
An overview of topical antifungal therapy in dermatomycoses. A North American perspective.皮肤真菌病的局部抗真菌治疗概述。北美视角。
Drugs. 1998 May;55(5):645-74. doi: 10.2165/00003495-199855050-00004.
3
Tioconazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses.噻康唑。对其抗微生物活性及在浅部真菌病治疗应用的综述。
Drugs. 1986 Jan;31(1):29-51. doi: 10.2165/00003495-198631010-00003.