Fredriksson T
Dermatologica. 1983;166 Suppl 1:14-9. doi: 10.1159/000249910.
A total of 60 patients with proven fungal infection of the skin took part in a single-blind comparative study of the efficacy, toleration and safety of tioconazole base 1% w/w and miconazole nitrate 2% creams applied twice daily for 14 days to patients with pityriasis versicolor and for 28 days to patients with dermatophyte and yeast infections. Overall assessment of the patients reviewed at the end of treatment showed that 23 of 30 patients (77%) treated with tioconazole and 19 of 30 patients (63%) treated with miconazole were clinically and mycologically cured. Tioconazole cured 80% (8 of 10) and miconazole cured 38% (5 of 13) of the infections with Trichophyton rubrum, which are the most frequent ones. At long-term follow-up, approximately 6 weeks later, results in both treatment groups were comparable. 20 of the 23 patients (87%) cured by tioconazole and 18 of the 19 patients (95%) cured by miconazole remained free from infection. Both creams were easy to apply and there were no reports of staining. No side effects were recorded during the study.
共有60例确诊为皮肤真菌感染的患者参与了一项单盲对照研究，该研究旨在比较1%w/w的噻康唑基质乳膏和2%硝酸咪康唑乳膏的疗效、耐受性和安全性。这两种乳膏均每日涂抹两次，花斑癣患者使用14天，皮肤癣菌和酵母菌感染患者使用28天。治疗结束时对患者进行的全面评估显示，使用噻康唑治疗的30例患者中有23例（77%）在临床和真菌学上治愈，使用咪康唑治疗的30例患者中有19例（63%）治愈。红色毛癣菌感染是最常见的感染类型，噻康唑对其治愈率为80%（10例中的8例），咪康唑为38%（13例中的5例）。在大约6周后的长期随访中，两个治疗组的结果相当。噻康唑治愈的23例患者中有20例（87%）、咪康唑治愈的19例患者中有18例（95%）未再感染。两种乳膏均易于涂抹，且无染色报告。研究期间未记录到副作用。
