Leiper J M, Lowe G D, Anderson J, Burns P, Cohen H N, Manderson W G, Forbes C D, Barbenel J C, MacCuish A C
Diabetes Res. 1984 May;1(1):27-30.
Blood rheology (blood viscosity, haematocrit, plasma viscosity, erythrocyte sedimentation and deformability) was measured in 22 diabetics in a study to compare animal insulins with biosynthetic human insulin. All rheological variables were significantly abnormal in the diabetics when compared with matched normal controls, and were not influenced by the type of insulin injected. However, blood rheology was related to diabetic control, as judged by glycosylated haemoglobin levels; when diabetic control was worst (mean glycosylated haemoglobin 11%), blood viscosity was significantly higher and red cell deformability significantly lower than when control was at its best (mean glycosylated haemoglobin 9.5%). A similar correlation between mean red cell deformability and mean glycosylated haemoglobin was found when individual diabetics were compared (r = 0.66; p less than 0.001). The occurrence of abnormal blood viscosity and red cell deformability during periods of poor diabetic control may contribute to the development of diabetic vascular complications.
在一项比较动物胰岛素和生物合成人胰岛素的研究中，对22名糖尿病患者进行了血液流变学（血液粘度、血细胞比容、血浆粘度、红细胞沉降和变形性）测量。与匹配的正常对照组相比，糖尿病患者的所有流变学变量均显著异常，且不受所注射胰岛素类型的影响。然而，根据糖化血红蛋白水平判断，血液流变学与糖尿病控制情况相关；当糖尿病控制最差时（平均糖化血红蛋白11%），血液粘度显著更高，红细胞变形性显著低于控制最佳时（平均糖化血红蛋白9.5%）。比较个体糖尿病患者时，发现平均红细胞变形性与平均糖化血红蛋白之间存在类似的相关性（r = 0.66；p小于0.001）。糖尿病控制不佳期间血液粘度和红细胞变形性异常的出现可能有助于糖尿病血管并发症的发展。
