Schut N H, van Arkel E C, Hardeman M R, Bilo H J, Michels R P, Vreeken J
Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
Acta Diabetol. 1993;30(2):89-92. doi: 10.1007/BF00578220.
A lower erythrocyte deformability, which causes impairment of the microcirculation, is postulated to contribute to diabetic organ complications. Erythrocyte deformability was measured in four groups of type 1 (insulin-dependent) diabetic subjects and 30 controls by filtration and ektacytometry. Twenty-five patients without organ complications, 21 with microalbuminuria, 13 with overt nephropathy and 12 with leg ulceration were studied. No decreased erythrocyte deformability was found in any of the diabetic groups with either technique, and neither did the total group of 71 diabetic subjects have a lower erythrocyte deformability when compared with the controls. In order to imitate local conditions in the kidney, erythrocyte deformability was also measured in hyperosmolar solutions. Again no differences were found between the diabetic groups separately or as a whole and the controls. Furthermore no correlation was found between erythrocyte deformability and the plasma glucose or glycosylated haemoglobin level.
红细胞变形性降低会导致微循环受损，据推测这会促使糖尿病器官并发症的发生。通过过滤法和激光衍射法血细胞分析技术，对四组1型（胰岛素依赖型）糖尿病患者和30名对照组人员的红细胞变形性进行了测量。研究对象包括25名无器官并发症的患者、21名微量白蛋白尿患者、13名显性肾病患者和12名腿部溃疡患者。采用这两种技术，均未在任何糖尿病组中发现红细胞变形性降低，而且71名糖尿病患者的总体红细胞变形性与对照组相比也没有降低。为了模拟肾脏的局部情况，还在高渗溶液中测量了红细胞变形性。糖尿病组单独或总体与对照组之间同样未发现差异。此外，红细胞变形性与血糖或糖化血红蛋白水平之间也未发现相关性。
