Fischer U, Jutzi E, Freyse E J, Salzsieder E
Endokrinologie. 1978 Feb;71(1):65-75.
Normal dogs were submitted to oral glucose loads or to intravenous glucose infusions. Insulin secretion rates (CISR) were calculated considering the resulting peripheral venous concentration differences in short intervals and the experimentally determined half life and apparent distribution space of exogenous insulin. Multiple regression analysis was done between CISR and both the level and the rate of change of plasma glucose. The regression coefficients were used as algorithm parameters for continuous plasma glucose dependent intravenous insulin administration in the same animals after induction of an insulin-dependent diabetes. Normal glycemic regulation over the day could be resotred by this sytem. The insulin responsiveness, however, varies from day to day; tusing this insulin dosage pattern we observed nearly normal plasma glucose curves and slightly elevated insulin reactions after glucose loading. This kind of algorithm could also be used in diabetic humans.
将正常犬口服葡萄糖负荷或静脉输注葡萄糖。胰岛素分泌率（CISR）是根据短时间内产生的外周静脉浓度差异以及实验测定的外源性胰岛素半衰期和表观分布容积来计算的。对CISR与血糖水平及变化率进行了多元回归分析。回归系数用作在同一动物诱导胰岛素依赖型糖尿病后，基于连续血糖依赖的静脉胰岛素给药的算法参数。该系统可恢复全天的正常血糖调节。然而，胰岛素反应性每天都有所不同；使用这种胰岛素剂量模式，我们观察到葡萄糖负荷后血浆葡萄糖曲线接近正常，胰岛素反应略有升高。这种算法也可用于糖尿病患者。
