Nilsson A, Hansson B G, Hökfelt B
Eur J Clin Pharmacol. 1978 Mar 17;13(1):5-8. doi: 10.1007/BF00606673.
Studies were performed in nine male patients with moderate hypertension. Treatment with metoprolol, 50--150 mg three times daily for 4--17 weeks, had no effect on the plasma level of glycerol, free fatty acids, triglycerides or glucose under basal conditions, neither in the supine nor in the upright position. Submaximal work, performed postprandially, increased plasma glycerol before medication but not during metoprolol, in spite of a marked increase in plasma noradrenaline. The work load employed caused no change in free fatty acids, triglycerides or glucose, neither before medication nor during metoprolol.
对9名中度高血压男性患者进行了研究。使用美托洛尔治疗，每日3次，每次50 - 150毫克，持续4 - 17周，在基础条件下，无论是仰卧位还是直立位，对甘油、游离脂肪酸、甘油三酯或葡萄糖的血浆水平均无影响。餐后进行次极量运动，用药前血浆甘油增加，但在服用美托洛尔期间没有增加，尽管血浆去甲肾上腺素显著增加。所采用的工作量对游离脂肪酸、甘油三酯或葡萄糖没有影响，用药前和服用美托洛尔期间均无变化。
