Doyle W J
Acta Otolaryngol Suppl. 1984;414:52-7. doi: 10.3109/00016488409122882.
In most infants and children with chronic otitis media with effusion, an inability to dilate the Eustachian tube actively has been documented. This functional tubal obstruction has been suggested to underlie the development of the disease. To test this possibility a variety of models using the Rhesus monkey were developed. The normal tubal dilatory system was impaired, resulting in sterile otitis media with effusion. The duration and nature of the disease was shown to be dependent on the severity and duration of the impairment in tubal function. These studies support the causative role of functional Eustachian tube obstruction in the development of otitis media with effusion and provide a series of models in which to study the etiology, pathogenesis, sequelae and complications as well as the treatment and preventions of the pathology in an animal species physiologically and anatomically similar to man.
在大多数患有慢性分泌性中耳炎的婴幼儿中，已有文献记载其咽鼓管无法主动扩张。这种功能性管腔阻塞被认为是该疾病发生的基础。为了验证这种可能性，开发了多种使用恒河猴的模型。正常的咽鼓管扩张系统受到损害，导致无菌性分泌性中耳炎。结果表明，疾病的持续时间和性质取决于咽鼓管功能损害的严重程度和持续时间。这些研究支持功能性咽鼓管阻塞在分泌性中耳炎发生中的致病作用，并提供了一系列模型，用于研究在生理和解剖学上与人类相似的动物物种中该病理的病因、发病机制、后遗症和并发症以及治疗和预防。
