Yamabe S, McCoy E C, Rosenkranz H S
Chemioterapia. 1984 Feb;3(1):60-2.
The Ames test indicated that ampicillin (ABPC) and its novel ester KBT-1585 were non-mutagenic for any of the tester strains of Salmonella typhimurium TA 98, TA 100, TA 1535 and TA 1538, both in the presence and in the absence of rat liver microsomal activation mixtures. Diacetyl, the first metabolite of KBT-1585 by the in vitro hydrolysis proved to be non-mutagenic for a new tester strain TA 102 which is exquisitely sensitive to ketones and aldehydes.
艾姆斯试验表明，氨苄青霉素（ABPC）及其新型酯KBT - 1585，无论在有无大鼠肝微粒体活化混合物存在的情况下，对鼠伤寒沙门氏菌TA 98、TA 100、TA 1535和TA 1538的任何测试菌株均无致突变性。KBT - 1585经体外水解产生的首个代谢产物双乙酰，对一种对酮类和醛类极其敏感的新测试菌株TA 102无致突变性。
