大鼠训练过程中海马神经细胞RNA代谢的研究。
Studies of RNA metabolism in the nerve cells of hippocampus during training in rats.
作者信息
Cupello A, Hydén H
出版信息
Exp Brain Res. 1978 Jan 18;31(1):143-52. doi: 10.1007/BF00235811.
PMID:639907
Abstract
Direct evidence is presented that training to change behavior initiates synthesis of specific species of mRNA in pyramidal nerve cells of CA3 of the hippocampus in rats. Reversal of handedness was used as goal-directed operant test and active controls. Newly synthesized poly(A) associated mRNA with S value of 25 and a stimulation of poly(A) lacking mRNA of 8--9 S and 16--17 S were found in the CA3 nerve cells of trained but not in active controls.
摘要
有直接证据表明，旨在改变行为的训练会引发大鼠海马体CA3区锥体细胞中特定种类mRNA的合成。将改变用手习惯作为目标导向的操作性测试和积极对照。在接受训练的大鼠的CA3神经细胞中发现了新合成的S值为25的与多聚腺苷酸（poly(A)）相关的mRNA，以及对缺乏多聚腺苷酸的8 - 9S和16 - 17S的mRNA的刺激，而在积极对照中未发现。
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