异吲哚酮对大鼠睾丸碱性磷酸酶的抑制性质
Nature of inhibition of rat testicular alkaline phosphatase by isatin.
作者信息
Kumar P, Nagpaul J P, Singh B, Bansal R C, Sharma R
出版信息
Experientia. 1978 Apr 15;34(4):434-5. doi: 10.1007/BF01935909.
PMID:639934
Abstract
Isatin has been found to inhibit rat testicular alkaline phosphatase (EC 3.1.3.1). That the inhibition is non-competitive as well as non-allosteric is evident from a) the hyperbolic curve relating inhibition as a function of inhibitor concentration; b) the small change in enthalpy, free energy and entropy; c) the number of isatin molecules associating with 1 molecule of the enzyme (n=1.29); and, d) the decrease in the values of both Km and Vmax in the presence of isatin.
摘要
已发现异吲哚酮可抑制大鼠睾丸碱性磷酸酶（EC 3.1.3.1）。从以下方面可明显看出这种抑制作用是非竞争性的且非别构性的：a）将抑制作用与抑制剂浓度相关联的双曲线；b）焓、自由能和熵的微小变化；c）与1个酶分子结合的异吲哚酮分子数（n = 1.29）；以及d）在存在异吲哚酮的情况下，Km和Vmax值均降低。
相似文献
1
Nature of inhibition of rat testicular alkaline phosphatase by isatin.异吲哚酮对大鼠睾丸碱性磷酸酶的抑制性质
Experientia. 1978 Apr 15;34(4):434-5. doi: 10.1007/BF01935909.
2
Isatin inhibition of rat testicular alkaline phosphatase. A non-allosteric phenomenon.异吲哚酮对大鼠睾丸碱性磷酸酶的抑制作用。一种非别构现象。
Enzyme. 1979;24(3):152-7. doi: 10.1159/000458647.
3
4
Isatin-enzyme interactions. VI. Inhibition of rat kidney alkaline phosphatase.
Enzyme. 1978;23(1):22-8.
5
Effect of administration of isatin on alkaline phosphatase of various organs of rat.异吲哚酮对大鼠各器官碱性磷酸酶的影响。
Indian J Physiol Pharmacol. 1978 Jul-Sep;22(3):297-300.
6
Rat testicular hyaluronidase--subcellular localization and interaction with isatin.大鼠睾丸透明质酸酶——亚细胞定位及与异吲哚酮的相互作用
Indian J Med Res. 1978 Jan;67:73-7.
7
Effect of isatin on testicular hyaluronidase.异吲哚酮对睾丸透明质酸酶的作用。
Indian J Exp Biol. 1977 Aug;15(8):655-6.
8
Rat kidney alkaline phosphatase : essential groups in catalysis & isatin inhibition.大鼠肾碱性磷酸酶：催化作用和异吲哚酮抑制中的必需基团。
Indian J Biochem Biophys. 1977 Mar;14(1):88-9.
9
Isatin enzyme interactions. V. Activation of rat liver acid phosphatase.
Enzyme. 1977;22(4):256-61.
10
The effect of isatin on the Echinococcus granulosus cyst in an experimental host.异吲哚酮对实验宿主细粒棘球绦虫囊肿的影响。
Vet Parasitol. 1988 Nov;30(1):31-44. doi: 10.1016/0304-4017(88)90140-9.
引用本文的文献
1
Effect of retinyl acetate feeding on the activity of testicular enzymes in young rats.喂食醋酸视黄酯对幼鼠睾丸酶活性的影响。
Experientia. 1980 May 15;36(5):545. doi: 10.1007/BF01965789.
本文引用的文献
1
ALLOSTERIC INHIBITION OF RAT LIVER FRUCTOSE 1,6-DIPHOSPHATASE BY ADENOSINE 5'-MONOPHOSPHATE.腺苷5'-单磷酸对大鼠肝脏果糖1,6-二磷酸酶的变构抑制作用
J Biol Chem. 1965 Feb;240:651-62.
2
The purification of aklaline phosphatases of animal tissues.动物组织碱性磷酸酶的纯化
Biochem J. 1954 Aug;57(4):595-603. doi: 10.1042/bj0570595.
3
Enzyme inhibition by isatin I. Inhibition of rat liver xanthine oxidase.异吲哚酮对酶的抑制作用I. 对大鼠肝脏黄嘌呤氧化酶的抑制作用
Enzymologia. 1969 Dec 31;37(5):325-34.
4
Effect of isatin on liver acid phosphatase of different species--a comparative study on rat & hedgehog, liver enzyme.异吲哚酮对不同物种肝脏酸性磷酸酶的影响——大鼠和刺猬肝脏酶的比较研究
Indian J Exp Biol. 1977 Jan;15(1):64-6.
5
Rat kidney alkaline phosphatase : essential groups in catalysis & isatin inhibition.大鼠肾碱性磷酸酶：催化作用和异吲哚酮抑制中的必需基团。
Indian J Biochem Biophys. 1977 Mar;14(1):88-9.
6
Isatin enzyme interactions. V. Activation of rat liver acid phosphatase.
Enzyme. 1977;22(4):256-61.
Zotero 插件