Paavonen J, Vesterinen E, Purola E, Jokipii A M, Jokipii L, Holttinen K, Vartiainen E
Scand J Urol Nephrol Suppl. 1984;86:237-40.
Seventy-nine unselected women whose main symptom was abnormal vaginal discharge were seen at the Department of Obstetrics and Gynecology at Helsinki University Central Hospital between October 1980 and September 1981. All patients and their current sex partners were randomly treated either with a 2-gram single dose of tinidazole or with identical placebos. Those excluded were 9 patients who did not attend the follow-up examination, 15 who had specific cervicovaginal infections (6 with chlamydial infection, 4 with trichomoniasis and 5 with yeast infection), and 22 with normal Döderlein flora seen on vaginal Pap smear. Response to the treatment was analysed among the remaining 33 women, of whom 17 received tinidazole and 16 placebo. The symptoms and signs that best discriminated between those who had normal Döderlein flora and those who had non-Döderlein flora were malodour, other than white colour of the discharge, and the presence of clue cells on Pap smear. When these findings were used to evaluate the response to treatment, tinidazole proved to be more effective than placebo. Disappearance of clue cells best (p less than 0.01) discriminated between tinidazole and placebo.
1980年10月至1981年9月期间，赫尔辛基大学中心医院妇产科接待了79名以阴道分泌物异常为主要症状的未经挑选的女性。所有患者及其现任性伴侣被随机给予2克单剂量替硝唑或相同的安慰剂进行治疗。被排除的患者有9名未参加随访检查，15名患有特定的宫颈阴道感染（6名衣原体感染、4名滴虫病和5名酵母菌感染），以及22名阴道巴氏涂片显示有正常的杜氏菌丛。对其余33名女性的治疗反应进行了分析，其中17名接受了替硝唑治疗，16名接受了安慰剂治疗。最能区分有正常杜氏菌丛和无杜氏菌丛患者的症状和体征是除了分泌物白色以外的恶臭以及巴氏涂片上出现线索细胞。当这些发现用于评估治疗反应时，替硝唑被证明比安慰剂更有效。线索细胞的消失最能（p小于0.01）区分替硝唑和安慰剂。
