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肾上腺素对心肌细胞中电生性钠泵的作用。

The effect of adrenaline on the electrogenic Na+ pump in cardiac muscle cells.

作者信息

Akasu T, Ohta Y, Koketsu K

出版信息

Experientia. 1978 Apr 15;34(4):488-90. doi: 10.1007/BF01935944.

DOI:10.1007/BF01935944
PMID:639946
Abstract

Electrogenic Na+ pump currents during K+-activated hyperpolarizations of bullfrog atrium muscle fibres are increased by adrenaline. The log dose-response relation between these currents and activating K+ concentrations is expressed by a sigmoidal curve, which is shifted in parallel to the left by adrenaline. It is suggested that adrenaline increases the rate of Na+ extrusion without increasing the Na/K coupling ratio and total number of pumping sites.

摘要

肾上腺素可增加牛蛙心房肌纤维钾离子激活超极化过程中的生电钠泵电流。这些电流与激活钾离子浓度之间的对数剂量-反应关系由一条S形曲线表示,该曲线在肾上腺素作用下平行向左移动。这表明肾上腺素增加了钠的外排速率,而不增加钠/钾偶联比率和泵位点的总数。

相似文献

1
The effect of adrenaline on the electrogenic Na+ pump in cardiac muscle cells.肾上腺素对心肌细胞中电生性钠泵的作用。
Experientia. 1978 Apr 15;34(4):488-90. doi: 10.1007/BF01935944.
2
Adrenaline and the electrogenic sodium pump in Rana catesbeiana sympathetic ganglion cells.肾上腺素与牛蛙交感神经节细胞中的生电钠泵
Experientia. 1976 Jan 15;32(1):57-9. doi: 10.1007/BF01932621.
3
Activation of the electrogenic Na-pump of cardiac muscle fibres by ACh in K-free solutions.
Experientia. 1979 Jun 15;35(6):772-3. doi: 10.1007/BF01968238.
4
Activation of electrogenic Na+ pump by epinephrine in bullfrog atrium.肾上腺素对牛蛙心房电生性钠泵的激活作用。
Jpn Heart J. 1977 Nov;18(6):860-6. doi: 10.1536/ihj.18.860.
5
An analysis of the effect of adrenaline on electrogenic Na+ pump of visceral nerve fibers in bullfrogs.肾上腺素对牛蛙内脏神经纤维电生性钠泵作用的分析
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6
Role of ion conductance changes and of the sodium-pump in adrenaline-induced hyperpolarization of rat diaphragm muscle fibres.离子电导变化及钠泵在肾上腺素诱导的大鼠膈肌纤维超极化中的作用。
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7
Indirect effects of acetylcholine on the electrogenic sodium pump in bull-frog atrial muscle fibres.乙酰胆碱对牛蛙心房肌纤维中电生性钠泵的间接作用。
J Physiol. 1988 May;399:519-35. doi: 10.1113/jphysiol.1988.sp017094.
8
The effect of adrenaline on the K+ -activated hyperpolarization of the sympathetic ganglion cell membrane in bullfrogs.肾上腺素对牛蛙交感神经节细胞膜钾离子激活超极化的影响。
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Acceleration of the electrogenic Na+ pump by adrenaline in frog skeletal muscle fibres.肾上腺素对蛙骨骼肌纤维中电生性钠泵的加速作用。
Life Sci. 1976 Oct 1;19(7):1009-13. doi: 10.1016/0024-3205(76)90292-7.
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Adrenaline-induced K+ efflux results in sodium pump stimulation in a sympathetic ganglion.肾上腺素诱导的钾离子外流导致交感神经节中钠泵的刺激。
Neurosci Lett. 1986 Oct 30;71(1):72-6. doi: 10.1016/0304-3940(86)90259-4.

引用本文的文献

1
Na(+)-K+ pump cycle during beta-adrenergic stimulation of adult rat cardiac myocytes.成年大鼠心肌细胞β-肾上腺素能刺激期间的钠钾泵循环
J Physiol. 1998 Mar 1;507 ( Pt 2)(Pt 2):527-39. doi: 10.1111/j.1469-7793.1998.527bt.x.
2
A kinetic analysis of the facilitatory action of adrenaline.肾上腺素促进作用的动力学分析。
Pflugers Arch. 1982 Jan;392(3):304-6. doi: 10.1007/BF00584316.
3
Desensitization of the muscarinic receptor of bullfrog atrial muscle.
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本文引用的文献

1
Increase of labeled calcium uptake in heart muscle during potassium lack contracture.缺钾挛缩期间心肌中标记钙摄取的增加。
J Gen Physiol. 1960 Jul;43(6):1193-206. doi: 10.1085/jgp.43.6.1193.
2
[On the membrane effect of adrenalin on the myocardial fiber].[论肾上腺素对心肌纤维的膜效应]
Pflugers Arch Gesamte Physiol Menschen Tiere. 1960;271:715-26.
3
[Effects of epinephrine on the resting potential of myocardial fibers of the auricle].[肾上腺素对心房肌纤维静息电位的影响]
4
Noradrenaline hyperpolarizes cells of the canine coronary sinus by increasing their permeability to potassium ions.去甲肾上腺素通过增加犬冠状窦细胞对钾离子的通透性使其超极化。
J Physiol. 1983 Jun;339:185-206. doi: 10.1113/jphysiol.1983.sp014711.
5
Activation of potassium transport induced by secretagogues in superfused submaxillary gland segments of rat and mouse.促分泌素诱导的大鼠和小鼠颌下腺灌流段钾转运激活
J Physiol. 1983 Aug;341:371-85. doi: 10.1113/jphysiol.1983.sp014811.
6
An effect of noradrenaline on resting potential and Na activity in sheep cardiac Purkinje fibres.去甲肾上腺素对绵羊心脏浦肯野纤维静息电位和钠活性的影响。
Pflugers Arch. 1986 Feb;406(2):144-50. doi: 10.1007/BF00586675.
7
Indirect effects of acetylcholine on the electrogenic sodium pump in bull-frog atrial muscle fibres.乙酰胆碱对牛蛙心房肌纤维中电生性钠泵的间接作用。
J Physiol. 1988 May;399:519-35. doi: 10.1113/jphysiol.1988.sp017094.
8
Contribution of the Na+/K+-pump to the membrane potential.
Experientia. 1987 Dec 1;43(11-12):1135-40. doi: 10.1007/BF01945511.
9
Activation of the electrogenic Na-pump of cardiac muscle fibres by ACh in K-free solutions.
Experientia. 1979 Jun 15;35(6):772-3. doi: 10.1007/BF01968238.
Experientia. 1956 Oct 15;12(10):396-8. doi: 10.1007/BF02157290.
4
The effect of adrenaline on the tension developed in contractures and twitches of the ventricle of the frog.肾上腺素对青蛙心室挛缩和抽搐时所产生张力的影响。
J Physiol. 1968 Jul;197(2):479-509. doi: 10.1113/jphysiol.1968.sp008571.
5
Voltage clamp experiments on ventricular myocarial fibres.心室肌纤维的电压钳实验。
J Physiol. 1970 Mar;207(1):165-90. doi: 10.1113/jphysiol.1970.sp009055.
6
Analysis of slow inhibitory postsynaptic potential of bullfrog sympathetic ganglion.
J Neurophysiol. 1968 Sep;31(5):717-28. doi: 10.1152/jn.1968.31.5.717.
7
The effect of adrenaline on the K+ -activated hyperpolarization of the sympathetic ganglion cell membrane in bullfrogs.肾上腺素对牛蛙交感神经节细胞膜钾离子激活超极化的影响。
Jpn J Physiol. 1976;26(3):289-301. doi: 10.2170/jjphysiol.26.289.
8
Adrenaline and the electrogenic sodium pump in Rana catesbeiana sympathetic ganglion cells.肾上腺素与牛蛙交感神经节细胞中的生电钠泵
Experientia. 1976 Jan 15;32(1):57-9. doi: 10.1007/BF01932621.
9
Acceleration of the electrogenic Na+ pump by adrenaline in frog skeletal muscle fibres.肾上腺素对蛙骨骼肌纤维中电生性钠泵的加速作用。
Life Sci. 1976 Oct 1;19(7):1009-13. doi: 10.1016/0024-3205(76)90292-7.
10
Activation of electrogenic Na+ pump by epinephrine in bullfrog atrium.肾上腺素对牛蛙心房电生性钠泵的激活作用。
Jpn Heart J. 1977 Nov;18(6):860-6. doi: 10.1536/ihj.18.860.