Crebelli R, Falcone E, Aquilina G, Carere A, Paoletti A, Fabri G
IARC Sci Publ. 1984(59):289-95.
A possible occupational contribution to urinary mutagenicity was studied in a tyre plant, by assaying concentrates of urine from 72 workmen and 23 controls for their activity in the Ames test and microtitre fluctuation test. The results show that smoking habits but not occupation are related to the appearance of a detectable urinary mutagenicity in strain TA98. A possible synergistic effect of occupation was, however, observed among tyre builders who were smokers. Mutagenicity screening of 25 rubber chemicals, of major technological relevance and used in high volume in the workplace investigated, showed that three of them are weakly active in TA98 and TA100 (tetramethylthiuram disulfide) or TA98 alone (poly-p-dinitrosobenzene and mixed diaryl-p-phenylendiamines).
通过检测72名工人和23名对照者尿液浓缩物在艾姆斯试验和微量滴定波动试验中的活性，对一家轮胎厂中职业因素对尿液致突变性的可能影响进行了研究。结果表明，吸烟习惯而非职业与TA98菌株中可检测到的尿液致突变性的出现有关。然而，在吸烟的轮胎制造工人中观察到了职业因素可能存在的协同作用。对25种在调查的工作场所大量使用且具有主要技术相关性的橡胶化学品进行的致突变性筛选表明，其中三种在TA98和TA100中活性较弱（二硫化四甲基秋兰姆），或仅在TA98中活性较弱（聚对二亚硝基苯和混合二芳基对苯二胺）。
